Changing the standard clinical approach towards the principles of personalized and integrative medicine.
Learn About the New Paradigm within Clinical Practice
Putting the patient in the center of focus, not the disease.
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Personalized Medicine - Integrated Approach to Patients

New Challenges, New Opportunities, New Success

Prof. Dalibor Krpan, MD, PhD

Welcome to International MSF

IMSF is a recently established society with the goal of promoting the new concept in the prevention and treatment of skeleton diseases, based on the principles of personalized and integrated medicine, in order to approach the skeleton as a complex organ which functions as a whole.

Why Do We Need a New Concept in Treatment of Chronic
 Skeleton Diseases?

Skeleton is a complex organ which must be considered as a whole. It consists of a number of bones and joints and at least three types of tissues: bone, cartilage and muscle-fibrotic tissue.

Skeleton is affected by many factors which can be grouped into genetic, bio-mechanical and metabolic. As the structure of the bone is constantly changing through a process of bone remodeling we can say that bone structure and quality is the result of all of these factors

Function of the skeleton depends on the structure and quality of all of its parts. Therefore it is always necessary to implement integrated treatment for the skeleton as a whole.

There are no diagnostic methods able to measure the bone strength or quality neither, of cartilage, nor to measure the quality of skeleton in general. Therefore we need to make a plan of treatment based on the assessment of skeleton status and risks of complication. Because there are significant diversities among the people regarding the influence of those factors, personalized approach in diagnostic evaluation and treatment is necessary.

Because it is not possible for the same therapeutic agent or a drug to act on all parts of the skeleton, it is necessary to implement a combination of several methods when conducting the treatment.

Common clinical practice regarding the treatment of chronic bone and joint diseases does not yield satisfactory results and does not accept any of the above facts. Therefore it is necessary to change the approach and introduce a new concept

One of the worst possible fates that can befall a person is to be mentally fit and with a great desire for life, but powerless and dependent on others. This is exactly what the effects of untreated osteoporosis lead to.

What is important to know about osteoporosis?

Osteoporosis is caused by the loss of bone quality not by the loss of bone mass. It can occur without the loss in bone mass. The bone quality depends more on the internal architecture of bone and quality of the material, and less on the weight of the bones.

Osteoporosis is not only the second disease in menopausal women, but since the internal structure of the bone is constantly changing through the process of bone remodeling, there are a lot of different factors affecting the quality of the bone, and therefore can affect younger women and men

Osteoporosis can lead to very serious consequences in terms of fractures and permanent disability. More women die due to complications caused by osteoporosis than from breast, uterine and ovarian cancers combined.

There is no cure for osteoporosis, nor a diagnostic method based on which we will determine the treatment. The choice of methods for treatment should be based on individual assessment issued by the doctor. Therefore, his experience and knowledge of the biology of bone is very important.

Complications caused by osteoporosis can be prevented by timely implementation of therapeutic measures which are usually simple and without side effects, including education, targeted exercises, and individually selected therapy based on diagnostic evaluation, which in most cases is non-invasive and inexpensive.

Why is there such a need for the new concept of Personalized Medicine in Helathcare Systems?
Because people are genetically different, they react differently to risk factors, diseases and to treatment. Therefore, in the case of chronic diseases, it is especially necessary to treat the patient and not a disease. This is also the best way to avoid unnecessary diagnostic tests and adverse effects of the long-term treatments needed in the case of chronic diseases.
What is the goal of Personalized medical care?
Putting the patient in the center of focus, not the disease. Examinations and treatments are planned according to the needs of each individual, providing a complete and integrated health care with the aim to treat and prevent chronic diseases.
What about timely prevention?
The human body is too complex and it is quite clear that the vast majority of health problems cannot be solved by organ replacement or conventional drug use. That is why there is an expanding trend in prevention and regenerative medicine. In fact, the disease is only the last phase of tissue and organ damage that began long before the onset of disease symptoms. It is therefore necessary to protect the tissue during the first signs of damage and as soon as possible regenerate the damaged organ.
Current Trends?
Personalized medicine is finding its place in most medical subspecialties, ophthalmology alike. Example of such personalized approach is treatment of severe corneal burns with consequent epithelial stem cell deficiency and vision loss. In such cases, only stem cells from autologous source are able to restore vision; thus, the treatment must be done in personalized manner. 
(Dekaris, Tominac-Trcin, Gabrić, Mijović, Pašalić; 2019 Springer Nature Switzerland AG)
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